NATIONWIDE PREVALENCE AND IMPACT OF PREDIABETES ON SEPSIS ADMISSIONS AMONG NON-DIABETICS IN 2017

TOPIC: Critical Care TYPE: Original Investigations PURPOSE: Diabetes mellitus is a known risk factor in the development of sepsis. Studies have shown worse outcomes critical patients with poor glycemic control, but recent meta-analysis showed improved sepsis diabetes. Considering inconclusive findings, we aim to further assess burden and admissions non-diabetics prediabetes. METHODS: The National Inpatient Sample (NIS), largest inpatient database United States was queried (2017) identify prediabetes using relevant ICD-10 CM diagnostic codes. Using weighted dataset, determined demographics, comorbidities, vs. without absence primary included all-cause mortality cardiopulmonary complications secondary patient disposition, length stay hospital charges. RESULTS: Of total 1,405,609 admissions, 14370 [median age 67 (54-78) yrs] were noted among (1%). prediabetic cohort often consisted geriatric (≥65 years: 54.9% vs 55.8%), male (51.1% 48.5%), white (61.7% 72.3%) non-elective (98% 97.1%) compared non-prediabetic (p<0.001). Prediabetic had higher frequency baseline comorbidities including hypertension (68.3% 57.5%), hyperlipidemia (46.6% 27.6%), obesity (27% 11%), smoking (39.8% 36.6%) peripheral vascular disease (11% 5.5%), demonstrated lower rates coagulopathy (18.1% 21.5%), alcohol abuse (3.1% 4.3%), pulmonary circulation disorder (1.2% 2.2%), fluid electrolyte disorders (46.9% 53.5%) Despite having cardiovascular factors, prediabetes-sepsis significantly odds (aOR 0.47 95%CI [0.44-0.51]), stroke 0.76 [0.65-0.90]), arrhythmia 0.91 [0.87-0.95]), cardiac arrest 0.36 95% CI [0.30-0.44]), septic shock 0.57 [0.54-0.60]), respiratory failure 0.70 [0.68-0.73]) support 0.68 [0.65-0.72]) cohort. Prediabetic-sepsis more routinely discharged (56.1% 39.9%) less transferred short-term or intermediate care facility (16.4% 27.9%) Furthermore, median (4 5 days) charges for prediabetic-sepsis CONCLUSIONS: All-cause half non-diabetics. also admissions. potential protective role impaired glucose state non-diabetic hospitalizations needs be studied. CLINICAL IMPLICATIONS: This first study reporting that confirmation through prospective studies find clinical application. DISCLOSURES: No relationships by Khizran Agha, source=Web Response Umarani Badarabandi, Prerna Bansal, Rupak Desai, Zainab Gandhi, Hiba ambreen, Bisharah Rizvi, Nayana Sasidharan, Harsh Sura,